work by decreasing sweat production from the eccrine and apocrine
sweat glands. Unfortunately most patients with hyperhidrosis do
not find commercial non-medical antiperspirants or deodorants useful
enough. One exception to this is Aluminum Chloride in high concentration
found in over the counter products.
Drysol is a solution of 20% Aluminum Chloride in anhydrous
ethyl alcohol. Drysol is a prescription only medication, which is
moderately effective in treating palmar and axillary hyperhidrosis.
However it may cause severe skin irritation. Drysol is applied to
the affected areas and left on for 6 hours. This is best done at
nighttime before going to sleep. The medication is then completely
washed off the next morning. Initial success rates are good but
long-term results are less satisfactory.
Xertac AC is another medical antiperspirant used in
treating hyperhidrosis, but it is not as effective as Drysol. Tannic
acid in ethanol and formalin solutions has also been used to treat
hyperhidrosis but they have been associated with allergic sensitization.
Other useful topical antiperspirants are Odaban and Maxim.
In general topical antiperspirants have to be
applied at nights and work best if used with saran wrap or plastic
gloves for maximal effect.
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